Bottle of melatonin supplements.

What Happens If You Take Expired Melatonin?

Written by: Dr James Pendleton

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Published

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Time to read 8 min

Melatonin supplements are commonly used to support sleep and manage jet lag, though their effectiveness varies by individual. But what happens if you take expired melatonin? While taking expired melatonin pills or gummies may not be dangerous, the potency of the active ingredients can decrease over time, making them less effective as a sleep aid.


Melatonin include expiration dates set by manufacturers, but their actual potency over time depends on storage conditions. Understanding melatonin expiration, potential side effects, and storage instructions can help ensure better sleep and avoid unwanted side effects.

Understanding Expired Melatonin

Melatonin is a naturally occurring hormone produced by the pineal gland that helps regulate the sleep-wake cycle. Many people take melatonin, including melatonin pills and gummies, to fall asleep faster or treat jet lag. As a dietary supplement, melatonin products are available over the counter and often used as a sleep aid for sleep problems and disorders. However, melatonin expires over time, raising concerns about its potency and effectiveness.

Illustration of the pineal gland producing melatonin.

What Does “Expired” Mean for Supplements?

Expiration dates on dietary supplements indicate when the product is expected to maintain its full potency and effectiveness. While melatonin expiration doesn’t necessarily make the supplement unsafe, it can cause a gradual loss of potency, reducing its ability to promote sleep. Manufacturer guidelines recommend following the expiration date printed on the packaging to ensure maximum effectiveness. Correctly stored melatonin may last longer, but taking expired melatonin could lead to reduced benefits.

"Correctly stored melatonin may last longer, but taking expired melatonin could lead to reduced benefits.”

A bottle of melatonin supplements.

Is It Safe to Take Expired Melatonin?

Taking expired melatonin is unlikely to be harmful, but its effectiveness in supporting sleep may decrease over time. Understanding the risks can help determine whether it’s still worth using expired melatonin products.

Potential Risks of Taking Expired Melatonin

Expired melatonin and fresh supplements may not work, leading to difficulty sleeping. While it is unlikely to cause serious harm, there are a few potential drawbacks:


  • Reduced potency and effectiveness – The active ingredients in melatonin supplements break down over time, making them less effective in promoting sleep.

  • Risk of consuming a less effective product – Taking expired melatonin may not provide the desired sleep aid benefits, especially for those relying on it for jet lag or sleep disorders.

  • Possibility of mild side effects – Some people may experience minor unwanted side effects from consuming older supplements, such as stomach discomfort or allergic reactions.

A concerned person checking the expiration date of supplements.

Can Expired Melatonin Make You Sick?

Expired melatonin is unlikely to cause severe illness, but degraded ingredients may lead to mild discomfort in some cases. Taking melatonin that has passed its expiration date may result in minor issues rather than serious health risks.


Common symptoms of consuming expired supplements include:


  • Upset stomach or mild nausea

  • Headache or dizziness

  • Allergic reaction, though rare

  • Reduced melatonin levels in the body due to lower potency

Person experiencing mild nausea and dizziness.

How Long Is Melatonin Good After Expiration?

Melatonin supplements nearing their expiration date may still be effective for a few months, but potency decreases over time. Many melatonin gummies and pills have a long shelf life if stored properly in a cool, dry place.


Many melatonin products may retain potency for up to one to two years if stored properly, though this can vary by formulation. Factors like exposure to heat, moisture, and air can speed up the breakdown of active ingredients, shortening their effectiveness. Following the manufacturer’s recommendations ensures the supplement works as intended.

Supplements in drawers.

Signs That Melatonin Has Gone Bad

Expired melatonin may lose effectiveness over time, but certain signs indicate it is no longer safe to use. Checking the supplement for changes in appearance, smell, or potency can help determine if it should be discarded.

How to Tell If Melatonin Is No Longer Effective

Melatonin, including melatonin pills and gummies, can degrade if exposed to heat, moisture, or air. Over time, the active ingredients may break down, making the supplement less effective in promoting sleep.


Signs that melatonin has expired or gone bad include changes in appearance, such as discoloration in pills or an unusual texture or smell in melatonin gummies. Additionally, expired melatonin may not provide the expected sleep-inducing effects, making it less effective in regulating the sleep cycle or treating jet lag.

Should You Use Melatonin That Looks or Smells Different?

If melatonin supplements have changed in color, texture, or smell, they should not be used. An altered appearance or odor could indicate the breakdown of active ingredients or contamination.


Checking the packaging for signs of damage, such as moisture exposure or broken seals, can help determine if the product is still safe. Following manufacturer guidelines ensures the supplement remains effective for better sleep.

What to Do If You’ve Taken Expired Melatonin

Most people will not experience serious side effects from taking expired melatonin, but it may not work as expected. Paying attention to any changes in how you feel can help determine the next steps.

Immediate Steps to Take

Monitoring for potential side effects is recommended if expired melatonin has been taken. Drinking water may help flush out any degraded ingredients, though most cases do not require medical attention.


Medical advice may be needed if symptoms like nausea, dizziness, or an allergic reaction occur. Those taking prescription drugs or other supplements should check with a doctor to avoid possible interactions.

Possible Reactions to Watch Out For

Expired melatonin is unlikely to cause severe health issues, but mild side effects can occur. Some symptoms may indicate the body is reacting to degraded ingredients or an ineffective dose.


Common symptoms to watch for include:


  • Upset stomach – Mild nausea or digestive discomfort.

  • Headache or dizziness – A possible reaction to decreased potency.

  • Drowsiness – Increased sleepiness at the wrong time due to inconsistent melatonin levels.


When to contact a healthcare provider: If symptoms persist or worsen or if an allergic reaction occurs.

A person drinking a glass of water.

How to Store Melatonin to Extend Its Shelf Life

Proper storage helps maintain the potency of melatonin supplements and ensures they remain effective for longer. Following storage instructions can prevent exposure to elements that break down active ingredients.

Best Storage Practices for Melatonin

Melatonin products should be kept in a cool, dry place, away from humidity and extreme temperatures. Storing melatonin pills and gummies in a medicine cabinet or pantry ensures they stay protected.


Heat, moisture, and direct sunlight can degrade the supplement, reducing its ability to promote sleep. Keeping the container tightly sealed and following the manufacturer’s recommendations helps preserve potency.

Can Refrigerating Melatonin Extend Its Potency?

Refrigerating melatonin may help extend its shelf life but is not always necessary. Cold temperatures can slow down the breakdown of active ingredients, keeping melatonin effective for a more extended period.


However, storing melatonin in the refrigerator may expose it to moisture, impacting potency. The best approach is to keep it in a dry, temperature-stable environment unless the manufacturer suggests refrigeration.

Alternatives to Expired Melatonin

If expired melatonin no longer works, using a fresh supplement or exploring natural alternatives can support better sleep.

Using Fresh Melatonin Supplements

A fresh melatonin supplement ensures the body receives the right dose for consistent sleep benefits. Many melatonin gummies and pills are available over the counter, offering a reliable option for those struggling with sleep problems.


Recommended dosages vary by age: Adults typically take 1–5 mg before bedtime, while children should use lower doses under medical guidance. Following dosage recommendations may support consistent sleep benefits and reduce the risk of side effects.

Natural Ways to Improve Sleep Without Melatonin

Lifestyle changes and natural remedies can help improve sleep quality without relying on melatonin. Maintaining a regular sleep schedule and limiting screen time before bed can support the body’s natural melatonin production.


Some people use herbal supplements like valerian root and chamomile to support relaxation and sleep, though research on their effectiveness is mixed. Establishing a bedtime routine, such as dimming lights and avoiding caffeine, can also help regulate the sleep cycle.

Bowl of dried valerian root.

Is It Worth the Risk of Taking Expired Melatonin?

Taking expired melatonin is unlikely to cause harm, but its effectiveness may be reduced. Melatonin supplements help regulate the sleep cycle, but as they expire, their potency decreases, making them less reliable for treating sleep problems or jet lag. Using fresh melatonin or exploring natural sleep aids ensures better results.


Consulting a healthcare professional before using expired supplements is the safest approach. If sleep issues persist, switching to a fresh melatonin product or considering other sleep aids may be a better option.

Frequently Asked Questions

Can You Use Melatonin Past Its Expiration Date?

While expired melatonin is unlikely to be harmful, its potency may decrease over time, reducing its effectiveness as a sleep aid.

How Long Does It Take for Melatonin to Work?

Typically, melatonin takes about 30 minutes to an hour to promote sleep; however, expired melatonin may have a delayed or diminished effect due to reduced potency.

What Are the Best Alternatives to Melatonin?

Natural sleep aids such as valerian root, magnesium, and chamomile tea can be effective alternatives to melatonin supplements.

Is It Safe to Take Expired Melatonin?

Consuming expired melatonin is generally safe but may not provide the desired sleep benefits due to decreased effectiveness over time.

How Should I Dispose of Expired Melatonin?

Check local disposal guidelines or mix expired melatonin with coffee grounds or kitty litter before placing it in the trash to prevent misuse.

REFERENCES

  1. Arendt J. (2005). Melatonin: characteristics, concerns, and prospects. Journal of biological rhythms, 20(4), 291–303. https://doi.org/10.1177/0748730405277492

  2. Bent, S., Padula, A., Moore, D., Patterson, M., & Mehling, W. (2006). Valerian for sleep: a systematic review and meta-analysis. The American journal of medicine, 119(12), 1005–1012. https://doi.org/10.1016/j.amjmed.2006.02.026

  3. Erland, L. A., & Saxena, P. K. (2017). Melatonin Natural Health Products and Supplements: Presence of Serotonin and Significant Variability of Melatonin Content. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 13(2), 275–281. https://doi.org/10.5664/jcsm.6462

  4. U.S. Food and Drug Administration. (2024). Expiration Dating Extension. https://www.fda.gov/emergency-preparedness-and-response/mcm-legal-regulatory-and-policy-framework/expiration-dating-extension

  5. Savage RA, Zafar N, Yohannan S, et al. Melatonin. [Updated 2024 Feb 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK534823/ 

Medically Reviewed By

Dr. James Pendleton

Dr. James Pendleton is a primary care physician specializing in a naturopathic approach to family medicine. He has nurtured a family practice in Seattle, directed a VIP medical center in Abu Dhabi, published several books and scientific articles, and designed innovative nutritional supplements for manufacturers worldwide.