Woman sleeping.

Melatonin: exceeding expectations

Written by: Mecene Research Team

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Published

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Time to read 8 min

Note From Dr. Pendleton


This article is my attempt at a simplified summary of a scientific paper I found interesting. I’m passionate about sharing scientific knowledge in a way that’s accessible to everyone. However, it's important to remember that many scientific studies, including this one, may not directly apply to you, let alone all people. For example, some studies are conducted on animals or involve small sample sizes, which limits the generalizability of the results. My goal is to present the information responsibly and in layman’s terms, so please keep in mind that the findings should be interpreted with care.


Medical Disclaimer: This article is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay seeking it because of something you have read on this website. The information in this article is based on a scientific review and should not be used as the sole basis for treatment decisions. Always consult with a healthcare professional before starting any new treatment or therapy.

Overview

The scientific article titled Melatonin: Exceeding Expectations by Russel J. Reiter, Dun Xian Tan, and Annia Galano explores the diverse and multifaceted roles of melatonin beyond its traditional association with sleep regulation. Published in 2014, the article highlights melatonin’s surprising range of functions, from its role as a powerful antioxidant protecting cells from oxidative damage to its involvement in immune support and anti-aging processes. Reiter and his colleagues provide a comprehensive review of the latest findings, demonstrating that melatonin is not just a sleep hormone but a versatile molecule with significant physiological and therapeutic potential across various medical fields.

Introduction

Melatonin is often called the "sleep hormone," but did you know it does much more than help you fall asleep? Scientists first discovered melatonin in the 1950s, thinking it only helped with sleep. However, over the years, they found that melatonin has many different jobs in our bodies. It’s like a superhero with multiple powers! This article will explore all the incredible ways melatonin helps our bodies stay healthy and strong.

The Role of Melatonin in Sleep

Melatonin is best known for helping you get a good night’s sleep. It works like a signal for your body, telling it when it’s time to go to bed and when it’s time to wake up. This happens because melatonin controls your internal clock, also known as your circadian rhythm.


When it gets dark outside, your body makes more melatonin, helping you feel sleepy and ready for bed. On the other hand, when it’s bright outside, melatonin levels drop, and you feel more awake.


How Light Affects Melatonin Production


Bright light, especially blue light from screens like phones, tablets, or TVs, can stop your body from making melatonin. The paper explains, “Light wavelengths in the range of 460-480 nm (blue light) inhibit melatonin synthesis in the pineal gland.”


This means that using electronic devices before bedtime can make it harder for you to fall asleep.


To help your body make melatonin naturally, try dimming the lights and avoiding screens at least an hour before you go to bed. Creating a calming bedtime routine can help you fall asleep more quickly and have a better night’s rest!

Woman sleeping soundly with bottle of melatonin on the night stand.

Melatonin as a Powerful Antioxidant

Melatonin is not just about sleep—it’s also a powerful antioxidant . Antioxidants are like shields that protect your cells from damage caused by harmful molecules known as free radicals. Free radicals can damage cells, making them age faster and even causing diseases like cancer and heart problems.


The research paper explains that "melatonin directly detoxifies reactive oxygen species (ROS) and reactive nitrogen species (RNS)," which are types of free radicals that can harm your body. Melatonin fights these free radicals to keep your cells healthy and strong. This is especially important in situations with a lot of oxidative stress, like during intense exercise, exposure to pollution, or when the body is healing from an injury.

How Melatonin Protects the Body

Melatonin helps protect your body in several notable ways:

Neutralizing Free Radicals

One of melatonin’s most impressive superpowers is its ability to neutralize free radicals. Free radicals are unstable molecules that can damage cells and lead to various health problems, like aging and diseases. These molecules form when the body faces stress from things like pollution, smoking, or even normal activities like exercise.


Melatonin acts like a shield, directly detoxifying these harmful molecules before they can cause damage. As the research explains, “melatonin improves the activities of several respiratory chain complexes, thereby reducing electron leakage and free-radical generation.” This means melatonin helps your cells make energy more efficiently while lowering the amount of harmful waste produced.

Boosting Cellular Health

Melatonin doesn’t stop at just neutralizing free radicals. It also plays a key role in protecting and maintaining the health of your cells. One way it does this is by supporting mitochondria, which are tiny power plants inside your cells that provide the energy your body needs to function. Mitochondria can be damaged by free radicals, but melatonin steps in to protect them.


The paper highlights that “melatonin’s antioxidant properties help maintain cellular health and prevent the onset of diseases linked to oxidative stress.” By keeping your mitochondria healthy, melatonin ensures that your cells continue to produce energy efficiently, which is essential for everything from muscle movement to brain function.


This powerful combination of reducing oxidative damage and supporting cell health is why melatonin is so important in preventing age-related decline and maintaining overall wellness.


Melatonin’s role as an antioxidant makes it essential to protect the body from various types of damage and keep cells healthy.

Melatonin and Your Immune System

Melatonin isn't just a sleep aid; it plays a crucial role in helping your immune system stay strong and ready to fight off infections. Think of your immune system as your body’s defense team, always on alert to protect you from harmful invaders like viruses, bacteria, and other pathogens. Melatonin works behind the scenes to keep this defense team in top shape, making sure your body can respond quickly and efficiently to threats.

Reducing Inflammation

One of melatonin’s most important jobs is helping your body manage inflammation. Inflammation is a natural response to injury or infection, where the body sends extra blood and immune cells to the affected area to heal it. While this process is essential for protecting the body, too much inflammation or uncontrolled inflammation can cause problems, leading to chronic pain, tissue damage, and even diseases.


The research paper notes that melatonin "helps balance inflammation levels in the body, promoting faster healing and protecting tissues." This means that melatonin works to calm down excessive inflammation, ensuring it doesn’t get out of control. By doing this, melatonin not only helps the body heal faster after an injury but also reduces the risk of long-term damage from overactive immune responses.


By supporting healthy inflammation levels and aiding in recovery, melatonin ensures that your immune system stays effective, helping protect your body from illnesses while promoting overall health.

Image depicting melatonin targeting inflammation.

Melatonin for Healthy Skin and Anti-Aging

Melatonin is also a skin superhero! It helps protect your skin cells from damage caused by the sun's UV rays , pollution, and other environmental stressors. The paper mentions that melatonin "protects skin cells from oxidative damage, helping to prevent premature aging and wrinkles."


Melatonin acts as a shield for your skin cells, keeping them safe from damage that can lead to wrinkles and other signs of aging. It also helps repair any damage that does occur, keeping your skin looking healthy and glowing.


Using melatonin lets your skin stay healthier and more youthful-looking for longer!

Where Does Melatonin Come From?

Many people think melatonin is only produced in the brain, but it's actually found all over the body and in many different organisms, including plants and animals. The research paper highlights that “melatonin is produced in all plants and animals that have been studied," which means it’s not just something unique to humans!

Foods That Naturally Contain Melatonin

You can boost your melatonin levels by eating certain foods. Here are some tasty examples:


  • Cherries: Fresh or dried cherries are great snacks that naturally contain melatonin.
  • Tomatoes: Adding tomatoes to your salads, sandwiches, or sauces can boost melatonin.
  • Walnuts: These nuts are not only delicious but also a good source of melatonin.

By eating these foods regularly, you can naturally increase the amount of melatonin in your body, which may help you sleep better and protect your health!

Tomatoes as one source of melatonin.

The Many Roles of Melatonin

Melatonin is far more than just a sleep hormone—it plays critical roles in protecting your body from damage and supporting overall health. As an antioxidant, it neutralizes harmful free radicals, reducing the risk of aging, cancer, and heart disease. It also boosts the immune system by controlling inflammation, aiding in faster healing, and preventing long-term damage. The research paper highlights melatonin’s ability to protect mitochondria, which are essential for energy production. With its presence in both plants and animals, melatonin has evolved as a universal defense molecule. Its multiple benefits, from sleep regulation to disease prevention, make it a key player in maintaining health, and further research could unlock even more of its therapeutic potential.

Meet the Author

Dr. James Pendleton

Dr. James Pendleton is a primary care physician specializing in a naturopathic approach to family medicine. He has nurtured a family practice in Seattle, directed a VIP medical center in Abu Dhabi, published several books and scientific articles, and designed innovative nutritional supplements for manufacturers worldwide.

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