Manganese mineral.

The Importance of Manganese Benefits in Longevity and Healthspan

Written by: Mecene Research Team

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Published

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Time to read 7 min

Manganese is one of the many essential trace minerals that play a crucial role in maintaining overall health and wellness. Though required in small amounts, its impact on the body is significant. This article explores the numerous benefits of manganese, its role in longevity, and how to ensure adequate intake through diet and supplements.

Different types of manganese supplements.

What Are Manganese Benefits?

Manganese is vital for human health because it involves various bodily functions. It supports enzyme activation, antioxidant defense, and bone health. Ensuring sufficient manganese intake can enhance well-being and promote a longer, healthier life.

Importance in Human Health

Manganese is not just a mineral; it’s a critical component of many physiological processes. Its importance in human health is broad, affecting bones, metabolism, and cellular protection. Here’s a closer look at why manganese is essential:


  • Bone Health: In terms of bone health, manganese contributes to the formation of bone tissue and helps maintain bone density, reducing the risk of osteoporosis.

  • Metabolism: It is integral in metabolizing carbohydrates, amino acid chelates, and cholesterol, helping the body utilize nutrients efficiently and supporting carbohydrate metabolism.

  • Antioxidant Defense: As a part of the enzyme superoxide dismutase, manganese helps protect cells from damage by neutralizing harmful free radicals.

"Ensuring sufficient manganese intake can enhance well-being and promote a longer, healthier life.”

How Does Manganese Impact Longevity?

Manganese plays a significant role in promoting longevity and improving healthspan. Its impact is seen in mitochondrial health and its anti-aging properties.

Manganese and Mitochondrial Health

Mitochondria are often referred to as the powerhouse of the cells, generating the energy required for numerous bodily functions. Manganese supports mitochondrial health in several ways:


  • Energy Production: Manganese aids in the production of enzymes necessary for cellular energy production.

  • Antioxidant Support: By supporting the antioxidant enzyme superoxide dismutase, manganese helps protect mitochondria from oxidative damage, preserving their function and reducing the risk of age-related diseases.

  • Cellular Efficiency: Manganese enhances the efficiency of mitochondria, ensuring they function optimally and provide the necessary energy for bodily functions.

  • Disease Prevention: Healthy mitochondria can lower the risk of chronic diseases linked to mitochondrial dysfunction, which aids diabetes mellitus patients.


Woman showing flawless skin due to manganese.

Manganese in Anti-Aging

Aging is a natural process, but manganese can help slow down its effects. This mineral contributes to anti-aging in various ways:


  • Collagen Formation: Manganese is essential for producing collagen, maintaining skin elasticity, and supporting wound healing.

  • Oxidative Stress Reduction: Its antioxidant properties help reduce oxidative stress, protecting cells from damage and potentially extending lifespan.

  • Skin Health: Manganese aids in the repair of damaged skin cells, promoting a youthful appearance and reducing wrinkles.

  • Joint Health: By supporting cartilage production, manganese helps maintain joint flexibility and reduces the risk of arthritis.

What Does Manganese Do in the Body?

Manganese supports various critical functions in the body, making it essential for overall health. This section delves into its specific roles in enzyme function and antioxidant defense.

Enzyme Function

Enzymes are biological catalysts that speed up chemical reactions in the body. Manganese is crucial for the activation of several important enzymes:


  • Metabolic Processes: It aids enzymes that convert food into energy, ensuring efficient metabolism of carbohydrates, amino acids, and cholesterol.

  • Bone Health: Manganese activates enzymes involved in the formation of bone tissue, contributing to the maintenance of strong bones due to the incredible absorption of calcium and trace minerals.

  • Hormone Production: Manganese helps in the synthesis of hormones that regulate various bodily functions.

  • Nutrient Absorption: It enhances the absorption of other essential nutrients, ensuring the body gets the maximum benefit from the diet. Manganese absorption can be influenced by iron levels, highlighting the importance of maintaining a balanced manganese and iron status for optimal health.

  • Enzyme Function: Manganese is a crucial component of manganese dependent superoxide dismutase, an enzyme that protects cells from oxidative damage.

Illustration on how manganese supports mitochondrial health.

Antioxidant Defense

Oxidative stress can lead to cell damage and chronic diseases. Manganese plays a vital role in the body’s antioxidant defense system:


  • Superoxide Dismutase: This manganese superoxide dismutase enzyme neutralizes free radicals, preventing them from causing cellular damage.

  • Cell Protection: By reducing oxidative stress, manganese helps protect cells, which is crucial for overall health and longevity.

  • Immune Support: Manganese boosts the immune system by protecting immune cells from oxidative damage.

  • Chronic Disease Prevention: Its antioxidant properties help lower the risk of chronic diseases like heart disease and cancer.

How Can You Get Enough Manganese?

To reap the benefits of manganese, it's important to ensure you're getting enough of it in your diet. This section covers dietary manganese sources and supplementation options.

Foods Rich in Manganese

Including manganese-rich foods in your diet is essential for maintaining adequate manganese levels. Some of the best sources with high manganese concentrations include:


  • Nuts and Seeds: Almonds, pecans, sunflower seeds, and flaxseeds have excellent manganese concentrations.

  • Whole Grains: Brown rice, oats, quinoa, and whole wheat provide a substantial amount of manganese.

  • Leafy Green Vegetables: Spinach, kale, and other leafy greens are rich in manganese.

  • Legumes: Chickpeas, lentils, and black beans are good sources of this mineral.

  • Fruits: Pineapple, blueberries, and blackberries contain significant amounts of manganese.

  • Seafood: Certain fish and shellfish can also provide a good amount of manganese concentrations.


Inadequate dietary intake can lead to decreased serum manganese levels, which may impact overall health.

Manganese Supplements

While it's best to get nutrients from food, manganese supplements can help when dietary manganese intakes are insufficient. Manganese supplements come in various forms:


  • Manganese Sulfate: Commonly used in supplements, manganese sulfate has a high absorption rate.

  • Manganese Gluconate: Manganese gluconate is a form often used for its bioavailability and effectiveness.

  • Manganese Aspartate: Another supplement form that can help ensure adequate manganese intakes.

  • Manganese Chelates: These are often combined with amino acids for improved absorption.


Safe Dosage Recommendations


  • Adults: The right dietary reference intakes for manganese is 2.3 mg per day for men and 1.8 mg per day for women.

  • Consult a Doctor: Always talk to a healthcare professional before starting any supplement regimen to avoid potential side effects or interactions with other medications.

  • Avoid Overconsumption: Stick to recommended dosages of manganese intakes to prevent the risk of manganese toxicity.

Image depicting manganese supplements.

Are There Risks in Manganese Supplementation and Deficiency?

While manganese is essential for health, too much can be harmful. This section highlights the potential risks and how to use manganese supplements safely.

Manganese Toxicity

Although manganese is essential, too much can be harmful. While rare, manganese deficiency can lead to serious health issues such as cognitive impairments and metabolic disturbances. Manganese toxicity can lead to various health issues:


  • Neurological Symptoms: Manganese neurotoxicity can cause symptoms like tremors, muscle stiffness, and other neurological problems.

  • Overexposure: People exposed to high levels of manganese dust, such as welders, are at higher risk of manganese toxicity.

  • Liver Disease: Excessive manganese can lead to chronic liver disease and affect the body’s ability to process other minerals.

  • Cognitive Impairment: Prolonged exposure to high levels of manganese can impair cognitive function and memory.


Research indicates that sex affects manganese absorption, with women generally absorbing more manganese than men, potentially due to differences in iron stores.

Safe Usage Tips

To ensure safe supplementation:


  • Consult a Healthcare Professional: Before starting any supplement regimen.

  • Follow Recommended Dosages: Adhere to the dietary manganese intake for reference.

  • Monitor for Toxicity: Watch for signs of manganese overdose, especially if taking supplements for an extended period.

  • Regular Check-Ups: Have regular health check-ups to monitor levels of manganese in the body.

  • Balanced Diet: Rely on a balanced diet to meet manganese needs and minimize the risk of overconsumption from supplements.

Image depicting enzyme function of manganese.

The Significance of Manganese for Longer Lifespan

Manganese is a vital trace mineral that supports various bodily functions, including enzyme activation, antioxidant defense, and bone health. By incorporating manganese-rich foods into your diet and using supplements cautiously, you can enjoy the numerous benefits of manganese, promoting overall health and longevity. Remember, a balanced diet and mindful supplementation are key to harnessing the full potential of manganese.

Frequently Asked Questions

Can Manganese Help with Other Health Conditions?

Yes, manganese supports bone health, regulates blood sugar, aids wound healing, and protects against oxidative stress and inflammation.

How Much Manganese Do I Need Daily?

Adult men need around 2.3 mg per day, and adult women need about 1.8 mg per day.

Can I Get Enough Manganese from Diet Alone?

Yes, a balanced diet with nuts, seeds, whole grains, leafy greens, and legumes can provide enough manganese.

Are There Any Side Effects of Taking Manganese Supplements?

Excessive intake can cause toxicity, including neurological problems, muscle pain, fatigue, and mood changes.

When Should I Consider Manganese Supplementation?

Consider supplementation if you have specific health conditions or dietary restrictions that prevent adequate intake.

REFERENCES

  1. Aschner, M., Erikson, K. M., & Dorman, D. C. (2005). Manganese dosimetry: species differences and implications for neurotoxicity. Critical reviews in toxicology, 35(1), 1–32. https://doi.org/10.1080/10408440590905920

  2. Chen, P., Bornhorst, J., & Aschner, M. (2018). Manganese metabolism in humans. Frontiers in bioscience (Landmark edition), 23(9), 1655–1679. https://doi.org/10.2741/4665

  3. Erikson, K. M., Thompson, K., Aschner, J., & Aschner, M. (2007). Manganese neurotoxicity: a focus on the neonate. Pharmacology & therapeutics, 113(2), 369–377. https://doi.org/10.1016/j.pharmthera.2006.09.002

  4. Li, L., & Yang, X. (2018). The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions. Oxidative medicine and cellular longevity, 2018, 7580707. https://doi.org/10.1155/2018/7580707

  5. Lucchini, R. G., Guazzetti, S., Zoni, S., Benedetti, C., Fedrighi, C., Peli, M., Donna, F., Bontempi, E., Borgese, L., Micheletti, S., Ferri, R., Marchetti, S., & Smith, D. R. (2014). Neurofunctional dopaminergic impairment in elderly after lifetime exposure to manganese. Neurotoxicology, 45, 309–317. https://doi.org/10.1016/j.neuro.2014.05.006

  6. Mehri A. (2020). Trace Elements in Human Nutrition (II) - An Update. International journal of preventive medicine, 11, 2. https://doi.org/10.4103/ijpvm.IJPVM_48_19 

Medically Reviewed By

Dr. James Pendleton

Dr. James Pendleton is a primary care physician specializing in a naturopathic approach to family medicine. He has nurtured a family practice in Seattle, directed a VIP medical center in Abu Dhabi, published several books and scientific articles, and designed innovative nutritional supplements for manufacturers worldwide.