Calm and relaxed woman.

Magnesium & L-Theanine for Calm and Sleep Support: What to Know

Written by: Mecene Research Team

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Published

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Time to read 8 min

If you’re trying to sleep better, you may have seen magnesium and L-theanine recommended together. Magnesium is often used to support physical relaxation, while L-theanine (an amino acid found in green tea) is commonly used to support a calmer, more settled mind. In this guide, we’ll break down how they work, how to time them, and what to watch for so you can decide if the pairing fits your routine.

What Is L-Theanine And Where Does It Come From?

L-theanine is commonly paired with magnesium. Some people use the combination to support relaxation and nighttime wind-down. It is an amino acid found naturally in green tea leaves and matcha, and in small amounts in some mushrooms. Some research suggests L-theanine may support alpha brain waves linked with a relaxed, alert state, which may help you feel relaxed.

What Is Magnesium And How Does It Support The Body?

Magnesium is commonly paired with L-theanine and is used by many people to support relaxation. It is an essential mineral involved in stress regulation, muscle relaxation, nervous system signaling, and sleep quality. Many adults are mildly deficient due to stress and diet. Common forms include glycinate for calming effects, citrate for digestive support, and oxide, which is less well absorbed.

Can You Take Magnesium And L-Theanine Together?

Magnesium and L-theanine are commonly used together by many healthy adults, but responses vary. No well-known interaction is commonly noted for most healthy adults, but it’s still smart to check labels and consider your situation. Effects can vary, since a small group may feel more alert from L-theanine rather than sleepy.

Bottles of magnesium & L-Theanine on a table.

What Benefits Can Magnesium And L-Theanine Offer Together?

Together, magnesium and L-theanine may support relaxation in both the mind and body, which can be helpful for stress and sleep.


  • Deeper relaxation (mind + muscles): Magnesium supports physical relaxation, while L-theanine supports a calm, “settled” mind.
  • Calmer thoughts and less tension: L-theanine may ease racing thoughts, and magnesium may help with muscle tightness.
  • Better stress support: The pairing may feel more balanced than using either one alone.
  • Improved sleep quality: Magnesium supports sleep-related body processes, and L-theanine may help you unwind at night.
  • Easier sleep onset: L-theanine may quiet mental activity, while magnesium supports readiness for rest.
  • Smoother wind-down after caffeine: L-theanine may take the edge off stimulation, and magnesium supports relaxation.

Do Magnesium And L-Theanine Work Better Together For Sleep?

Magnesium and L-theanine can support sleep for some people, but not everyone responds the same. Below are two simple sections that cover how the pairing may help and how to try it in a way that’s easy to track.

How Magnesium + L-Theanine May Support Sleep Quality

Magnesium supplements support the nervous system and muscle relaxation, which can help your body settle and support sleep regulation. L-theanine is an amino acid found in green tea leaves and is common in L-theanine supplements. It’s often used to promote relaxation and support calmer brain waves like alpha brain waves.


Together, the magnesium L-theanine combo may support stress relief and a calmer wind-down at night, which can support sleep quality for some people. But for some people, taking L-theanine can feel a little energizing, which may affect sleep onset and sleep latency.

"Together, the magnesium L-theanine combo may support stress relief and a calmer wind-down at night, which can support sleep quality for some people."

How To Try Magnesium And L-Theanine Together Without Guessing

Start simple so you can tell what’s working. Try one ingredient first, then combine L-theanine with magnesium later if needed, using a low dose and avoiding high doses at the start.


Track changes in sleep quality, how fast you fall asleep, and how you feel the next day (calm, focused, groggy, or wired). Adjust timing based on your body: some people use L-theanine earlier for stress support, then take magnesium at night to support sleep.


If you’re using other medications, stacking multiple dietary supplements, or adding over-the-counter sleep aids like melatonin, check with a healthcare provider first.

Helps The Body Respond To Stress Long-Term

Ashwagandha helps support the body’s stress response over time. It is linked to cortisol levels and broader stress systems tied to chronic stress. Consistent use matters for benefits.

May Support Sleep, Hormonal Balance, And Resilience

Some research shows ashwagandha may support sleep quality and stress resilience. It is also studied for effects on overall well-being and hormonal balance. These health benefits tend to appear gradually.

Takes Longer To Build Effects Than L-Theanine

Ashwagandha works slowly compared to L-theanine. Effects often take days or weeks with consistent use. This improves long-term stress support.

Person holding a glass of water.

What’s The Best Time To Take Magnesium And L-Theanine?

The best time to take magnesium and L-theanine depends on your goal. For sleep support, many people take them in the evening. If sleep is the goal, some people take L-theanine earlier in the day and avoid taking it too close to caffeine, since caffeine can affect sleep timing.

Any Side Effects When Taking Them Together?

Side effects are usually mild, but they can happen. Your response depends on the dose, the form of magnesium supplements or L-theanine supplements, and your sensitivity, especially if you’re taking other medications or other dietary supplements.

L-Theanine Side Effects

Possible effects include headache, vivid dreams, or increased alertness. These effects are uncommon but can occur. Lowering the dose may help.

Magnesium Side Effects

Magnesium may cause loose stool or stomach upset, depending on the form. Citrate is more likely to affect digestion than glycinate. Adjusting the form or dose often improves tolerance.

When To Stop Or Reduce Your Intake

If side effects don’t go away or start to interfere with your day, it’s a good sign to stop or lower your intake.


  • Stop or reduce if side effects persist after a few days

  • Reassess if your sleep worsens or if you feel more wired or groggy than usual

  • Cut back if you have ongoing digestive discomfort (like loose stool or stomach upset)

  • Pause if you notice unusual symptoms that don’t feel normal for you

  • Check with a healthcare provider if symptoms continue, feel concerning, or if you’re taking other medications

Who Each One Suits Best

Busy professionals and caffeine drinkers often prefer L-theanine. People dealing with chronic stress or sleep disorders often prefer ashwagandha. Personal stress patterns matter. Lifestyle, timing, and sensitivity to supplements can also influence which option feels like a better fit.

Person in bed covering their eyes with their hands.

Who Should Avoid Taking Magnesium And L-Theanine?

Some people should use extra caution and talk with a healthcare provider. This includes people who are pregnant or breastfeeding, or who have kidney concerns. It also includes anyone taking other medications.

Natural Food Sources Of Magnesium And L-Theanine

Magnesium and L-theanine can also be obtained from food, not just supplements. Food sources may provide gentler support for calm and sleep, especially for those sensitive to higher doses. Using food sources can be a simple way to support overall well-being alongside supplements.

Foods Rich In Magnesium

Spinach, pumpkin seeds, almonds, and dark chocolate are sources of magnesium. These foods support overall nutrient intake and play key roles in muscle and nerve function. They can complement or replace supplements depending on individual needs.

Foods And Drinks With L-Theanine

Green tea, matcha, and black tea naturally contain L-theanine. These also contain caffeine, which can affect sleep timing and alertness. Caffeine intake should be considered if sleep support is the goal.

Glass of matcha green tea on a wooden table.

Should You Try Magnesium And L-Theanine Together?

Magnesium and L-theanine are often used together by many healthy adults, but responses vary by dose and timing, so it helps to start low and adjust based on whether you want daytime calm or nighttime rest. If you’re trying this pairing for sleep, focus on the basics first (consistent bedtime, less late caffeine, and a simple wind-down routine), then track how your sleep feels for a week before changing anything. If you notice you feel weird, groggy, or off, tweak the timing, lower the dose, or pause and reassess. Small changes usually tell you more than stacking more supplements.


If you prefer getting L-theanine from a drink instead of a capsule, try Mecene’s Organic Matcha Green Tea. Just keep in mind that matcha contains caffeine, so it’s usually better earlier in the day if sleep is your main goal.

Frequently Asked Questions

Is it safe to take magnesium and L-theanine together?

Yes, they’re generally safe together for most healthy adults.

Do magnesium and L-theanine make you sleepy?

They may promote calm, but L-theanine can increase alertness in some people.

Can I take magnesium with green tea?

Yes, you can take magnesium with green tea, but it may slightly reduce magnesium absorption, so take them at different times.

What’s the best magnesium type to pair with L-theanine?

Magnesium glycinate is often preferred for relaxation and sleep.

Should I take magnesium and L-theanine in the morning or at night?

Evening is common for sleep support; morning may help with daytime calm.

REFERENCES

  1. Cleveland Clinic. (2023, July 19). Here’s what you need to know about L-theanine. Cleveland Clinic Health Essentials. https://health.clevelandclinic.org/l-theanine

  2. Cuciureanu MD, Vink, R. Magnesium and stress. In: Vink R, Nechifor M, editors. Magnesium in the Central Nervous System [Internet]. Adelaide (AU): University of Adelaide Press; 2011. Available from: https://www.ncbi.nlm.nih.gov/books/NBK507250/

  3. National Institutes of Health, Office of Dietary Supplements. (2025). Magnesium: Fact sheet for health professionals. U.S. Department of Health and Human Services. https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/

  4. University of Rochester Medical Center. (n.d.). Magnesium-rich foods for children and families. URMC Children’s Hospital Nutrition. https://www.urmc.rochester.edu/childrens-hospital/nutrition/magnesium-foods

  5. Shilo, L., Sabbah, H., Hadari, R., Kovatz, S., Weinberg, U., Dolev, S., Dagan, Y., & Shenkman, L. (2002). The effects of coffee consumption on sleep and melatonin secretion. Sleep medicine, 3(3), 271–273. https://doi.org/10.1016/s1389-9457(02)00015-1

  6. Sleep Foundation. (n.d.). Magnesium for sleep. https://www.sleepfoundation.org/magnesium

Medically Reviewed By

Dr. James Pendleton

Dr. James Pendleton is a primary care physician specializing in a naturopathic approach to family medicine. He has nurtured a family practice in Seattle, directed a VIP medical center in Abu Dhabi, published several books and scientific articles, and designed innovative nutritional supplements for manufacturers worldwide.