Different supplements on a table.

The Best Supplements for Longevity

Written by: Mecene Research Team

|

Published

|

Time to read 7 min

As we age, keeping our health and energy up becomes more important. Many people use supplements to help them live longer and healthier lives. This article will discuss the best longevity supplements and how they help with healthy aging. But remember, supplements work best when combined with a balanced diet and healthy lifestyle choices.

A variety of supplements on a table.

Overview of Using Supplements to Support Longevity

Using supplements to support longevity is becoming more popular. These supplements can fill in nutritional gaps, improve how our bodies work, and protect against age-related diseases.


Important supplements like vitamin D, omega-3 fatty acids, and antioxidants help us stay healthy and reduce the risk of diseases. Clinical trials and scientific studies show that these nutrients can support brain health, improve immune function, and help cells function properly.


Benefits of Supplements for Longevity


  • Support brain health: Helps prevent mild cognitive impairment.

  • Enhance immune function: Strengthens the immune system to fight off diseases.

  • Promote healthy cell function: Keeps cells working properly and reduces oxidative stress.

  • Reduce the risk of chronic diseases: Lowers the chances of conditions like heart disease and high blood pressure.

"Supplements work best when combined with a balanced diet and healthy lifestyle choices."

Importance of Diet and Lifestyle Alongside Supplementation


Supplements can provide essential nutrients but shouldn't replace a healthy diet and lifestyle. Eating nutritious foods rich in vitamins and minerals, like fruits, vegetables, whole grains, and lean proteins, is vital for long-term health.


Regular physical activity, maintaining a healthy weight, and managing stress are also necessary for a healthy life. These factors can help prevent chronic diseases like cardiovascular disease, high blood pressure, and cognitive decline, supporting a longer life.


Key Lifestyle Factors


  • Balanced diet: Eat various healthy foods for the necessary vitamins and minerals.

  • Regular exercise: Engage in activities like walking, jogging, or resistance training.

  • Stress management: Practice mindfulness, meditation, or hobbies to reduce stress.

  • Adequate sleep: Ensure 7-9 hours of quality sleep per night.

Woman holding supplements with healthy food as background.

Vitamin D

Vitamin D is crucial for bone, muscle, and heart health. It helps the body absorb calcium, which keeps bones strong. Vitamin D also supports muscle function and cardiovascular health. It may help regulate inflammation and boost immune health.


Benefits of Vitamin D


  • Bone health: Strengthens bones and prevents osteoporosis.

  • Muscle function: Improves muscle strength and reduces the risk of falls.

  • Heart health: Supports cardiovascular health and helps prevent heart disease.

  • Immune support: Enhances immune system function to fight infections.

  • Recommended Daily Intake: Adults should aim for 600-800 IU of vitamin D daily. Spending time in the sunlight and eating fortified foods can help meet these needs, but supplements are often necessary, especially for older adults or those with limited sun exposure.

Omega-3 Fatty Acids

Omega-3 fatty acids are essential for brain, eye, and heart health. These healthy fats, found in fish oil, algae oil, and some plants, improve brain health and reduce the risk of cardiovascular disease.


Benefits of Omega-3 Fatty Acids


  • Brain health: Supports cognitive function and reduces the risk of neurodegenerative diseases.

  • Eye health: Essential for maintaining good vision and eye health.

  • Heart health: Lowers the risk of heart disease and improves blood vessel health.

  • Anti-inflammatory: Reduces inflammation in the body, which can help prevent chronic diseases.

  • Daily Recommendation: Aim for 500-1000 mg of EPA/DHA (types of omega-3s) per day. Including fatty fish like salmon in your diet or taking high-quality fish oil supplements can help achieve this.

Probiotics


Probiotics are beneficial bacteria that improve gut health and immune function. They aid digestion, enhance nutrient absorption, and support a healthy immune system. Probiotics can be found in fermented foods like yogurt, kefir, and sauerkraut, as well as in dietary supplements.


Benefits of Probiotics


  • Gut health: Improves digestion and reduces symptoms of digestive disorders.

  • Immune function: Strengthens the immune system and helps fight infections.

  • Nutrient absorption: Enhances the absorption of vitamins and minerals from food.

  • Digestive health: Helps maintain a healthy balance of gut bacteria.

  • Choosing Probiotics: Look for multi-strain formulas with billions of CFUs (colony-forming units) to ensure a diverse range of beneficial bacteria.

Image of yogurt.

Magnesium

Magnesium is involved in hundreds of processes in the body, including energy production, glucose metabolism, and muscle function. A magnesium deficiency is associated with an increased risk of chronic diseases like heart disease and type 2 diabetes.


Benefits of Magnesium


  • Energy production: Helps convert food into energy.

  • Glucose metabolism: Regulates blood sugar levels and supports insulin sensitivity.

  • Muscle function: Prevents muscle cramps and supports muscle relaxation.

  • Heart health: Reduces the risk of cardiovascular disease and promotes overall heart health.

  • Recommended Daily Intake: Adults should aim for 310-420 mg of magnesium daily. Foods like leafy greens, nuts, seeds, and whole grains are good sources, but supplements may be necessary to meet daily requirements.

Antioxidants Like Resveratrol

Antioxidants, such as resveratrol, protect against cell damage from free radicals. These powerful antioxidants can be found in fruits, vegetables, red wine, and supplements. They support cellular health, reduce oxidative stress, and may have anti-aging effects.


Benefits of Resveratrol


  • Cellular health: Protects cells from damage and supports healthy cell function.

  • Oxidative stress reduction: Neutralizes harmful free radicals in the body.

  • Anti-aging effects: This may slow the aging process and promote a longer lifespan.

  • Heart health: Supports cardiovascular health and reduces the risk of heart disease.

  • Sources of Resveratrol: Eat foods like grapes, berries, and peanuts, or consider taking resveratrol supplements to enhance your antioxidant intake.

Red wine being poured in a glass wine.

Lifestyle Lessons from the Blue Zones

Blue Zones are regions where people live significantly longer and healthier lives. These areas include Okinawa in Japan, Sardinia in Italy, Nicoya in Costa Rica, Ikaria in Greece, and Loma Linda in California. People in these regions often live to be 100 years old or more. By studying these areas, we can learn valuable lessons about healthy aging and how to live a longer, happier life.


Plant-Based Diets


People in Blue Zones typically follow plant-based diets. This means they eat lots of beans, greens, nuts, and seeds. These foods are packed with essential nutrients and fiber that support good health.


  • Beans: Beans like black beans, chickpeas, and lentils are rich in protein, fiber, and vitamins. They help maintain healthy blood sugar levels and provide long-lasting energy.

  • Greens: Vegetables such as spinach, kale, and broccoli are high in vitamins A, C, and K. They are also full of antioxidants, which help protect cells from damage.

  • Nuts and Seeds: Almonds, walnuts, and chia seeds are good sources of healthy fats, protein, and fiber. They can help reduce the risk of heart disease and improve brain health.

Selection of beans.

Physical Activity


People in Blue Zones stay active daily but don't necessarily go to the gym. Instead, they incorporate physical activity into their daily routines through walking, gardening, and other forms of exercise.


  • Walking: Walking is a simple and effective way to stay fit. It strengthens the heart, improves circulation, and boosts mood.

  • Gardening: Gardening provides physical exercise, reduces stress, and increases exposure to fresh air and sunlight.

  • Daily Chores: Activities like cleaning the house or doing yard work also count as physical exercise and help keep the body moving.


Social Engagement


Having a strong sense of community is common in Blue Zones. People maintain close relationships with family and friends, which provides emotional support and reduces stress.


  • Family Time: Spending quality time with family members helps strengthen bonds and create happy memories.

  • Friendships: Having a network of friends offers support during tough times and enhances overall well-being.

  • Community Activities: Participating in community events and group activities fosters a sense of belonging and purpose.


Sense of Purpose


People in Blue Zones have a clear sense of purpose. They know why they wake up daily and feel valued and needed by their communities. This sense of purpose is known as "ikigai" in Japan and "plan de vida" in Costa Rica.


  • Ikigai: In Okinawa, having a sense of purpose, or "ikigai," is considered a reason for living. It can be anything from a hobby to a responsibility within the family.

  • Plan de Vida: In Nicoya, the "plan de vida," or life plan, involves setting goals and having something to look forward to each day.

  • Volunteering: Helping others through volunteering can also provide a sense of purpose and increase feelings of happiness and fulfillment.

Woman doing volunteer work.

Conclusion: Taking the Best Supplements for Longevity

Research on supplements for longevity is still emerging, but key nutrients like vitamin D and omega-3s show promise in optimizing health and supporting healthy aging.


Combining strategic supplementation with a balanced diet, regular physical activity, and other healthy lifestyle choices can help promote a longer, healthier life. As always, please consult a healthcare provider before starting any new supplement regimen to ensure it fits your health needs and goals.

Frequently Asked Questions

What are the best supplements for longevity?

The best supplements for longevity include vitamin D, omega-3 fatty acids, probiotics, magnesium, and antioxidants like resveratrol.

How can I improve my brain health with supplements?

Supplements like omega-3 fatty acids, vitamin D, and probiotics can help improve brain health and cognitive function.

What is the recommended daily intake of vitamin D for adults?

Adults should aim for 600-800 IU of vitamin D per day.

Why are antioxidants important for aging?

Antioxidants protect cells from damage caused by free radicals, helping to reduce oxidative stress and slow aging.

How do probiotics benefit gut health?

Probiotics improve gut health by aiding digestion, enhancing nutrient absorption, and supporting a healthy balance of gut bacteria.

REFERENCES

  1. Baur, J. A., & Sinclair, D. A. (2006). Therapeutic potential of resveratrol: the in vivo evidence. Nature reviews. Drug discovery, 5(6), 493–506. https://doi.org/10.1038/nrd2060

  2. Calder P. C. (2016). Docosahexaenoic Acid. Annals of nutrition & metabolism, 69 Suppl 1, 7–21. https://doi.org/10.1159/000448262

  3. DiNicolantonio, J. J., O'Keefe, J. H., & Wilson, W. (2018). Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open heart, 5(1), e000668. https://doi.org/10.1136/openhrt-2017-000668

  4. Holick M. F. (2007). Vitamin D deficiency. The New England journal of medicine, 357(3), 266–281. https://doi.org/10.1056/NEJMra070553

  5. Pizzorno J. (2014). Glutathione!. Integrative medicine (Encinitas, Calif.), 13(1), 8–12.

  6. Poulose, S. M., Miller, M. G., & Shukitt-Hale, B. (2014). Role of walnuts in maintaining brain health with age. The Journal of nutrition, 144(4 Suppl), 561S–566S. https://doi.org/10.3945/jn.113.184838

  7. Sanders, M. E., Merenstein, D. J., Reid, G., Gibson, G. R., & Rastall, R. A. (2019). Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nature reviews. Gastroenterology & hepatology, 16(10), 605–616. https://doi.org/10.1038/s41575-019-0173-3

Medically Reviewed By

Dr. James Pendleton

Dr. James Pendleton is a primary care physician specializing in a naturopathic approach to family medicine. He has nurtured a family practice in Seattle, directed a VIP medical center in Abu Dhabi, published several books and scientific articles, and designed innovative nutritional supplements for manufacturers worldwide.